殷志琦,女,博士,副教授,硕士研究生导师,天然药物化学教研室副主任。
学习、工作经历
2014.4-至今中国药科大学天然药化教研室教研室副主任
2013.4-2014.4美国伊利诺伊大学芝加哥校区药学院(访问学者/副教授)
2003.3-2004.3香港科技大学生物系(访问学者)
2002.7-2013.4中国药科大学天然药化教研室副教授
2001.2-2002.2香港科技大学生物系(访问学者)
1997.9-2002.6中国药科大学药物化学专业博士学位
荣誉和兼职
江苏省高校“青蓝工程”优秀青年骨干教师培养对象
江苏省第九批“六大人才高峰”高层次人才
第三届江苏省中医药十佳青年之星
药学会成员
Chinese Chemical Letters青年编委
国家自然科学基金医学部同行评议专家
南京市、山东省、吉林省科技评审专家
Food Hydrocolloids、Food and Function、Phytomedicine、Natural Product Research、Molecules、Fitoterapia、Chinese Chemical Letters、中国天然药物等杂志审稿人
研究方向
1.招生方向
1007Z9★天然药物化学:天然药物与中药的活性成分研究
1008Z1★中药化学:中药化学成分研究及新药开发
2.研究方向
(1)新颖骨架/结构天然化合物的发现与活性研究
(2)治疗代谢综合症(如高血脂、糖尿病、肥胖、非酒精性脂肪肝等)的中药和天然药物的研究与开发
(3)天然小分子靶向药物的发现、构效关系和作用机制的研究及应用,包括肿瘤靶向药物和诊断试剂,心肌活性诊断试剂,影像对比剂的研究、构建与开发。
研究成果
1.教学成果
承担本科生《天然药物化学》、《波谱解析》、《专业英语》,研究生《中药、天然药物研究基础、方法与思路》等课程。
作为主讲教师之一的《天然药物化学》获国家级、省级、校级精品课程;荣获江苏省高等学校优秀多媒体教学课件一等奖1项,省级微课比赛二等奖1项、校级教学成果一等奖1项,校级优秀多媒体教学课件竞赛获二等奖等。
参与编写教材《天然药物化学实验与指导》(双语)以及《中药制药化学》,均已出版。
2.科研成果
课题资助
a)国家自然科学基金:基于TrkB靶标研究杠柳和青阳参中去氧糖类成分抗癫痫活性的作用机制和构效关系(2011.1-2013.12,编号81001379,主持)b)中央高校基本科研业务费专项资金扶贫项目:镇坪道地药材黄连降血脂药效物质基础比较研究(2014.1-2014.12,主持)c)江苏省第九批“六大人才高峰”高层次人才项目(2013.1-2015.12,编号2012-YY-008,主持)d)江苏省高校“青蓝工程”优秀青年骨干教师(2010.12-2012.12,主持)e)中国药科大学中央高校基本科研业务费专项资金重点项目:基于TrkB靶标研究去氧糖类成分抗癫痫活性的作用机制和构效关系(2010.7-2013.6,主持)f)“重大新药创制”科技重大专项“十一五”计划:猪牙皂总皂苷治疗类风湿关节炎候选药物研究(2009.1-2010.12,编号2009ZX09103-392,第二,药学部分负责人,完成)g)江苏省高校自然科学研究计划项目:苏北沿海滩涂植物中华补血草抗肿瘤作用的发现与研究(2008.07-2010.12,编号08KJB360011,参加,完成)
h)国家自然科学基金:桑树中氮糖化合物与其内生菌相关性研究(2005.1-2007.12,编号30472146,参加,完成)
i)教育部科学技术研究项目:桑树中具降糖活性的氮糖类化合物与其内生菌相关性研究(2003年7月-2005年7月,编号104098,参加,完成)
研究生培养
协助指导博士2人(已毕业)和硕士研究生15人,独立指导硕士研究生34人
1名科学硕士和1名专业硕士的毕业论文荣获2015年江苏省优秀硕士论文
近期代表性论文(已发表研究论文近100篇)
[1]XuejiaoLiu, Cuihua Jiang, Dongjian Zhang, Meng Gao, Fei Peng, Dejian Huang, Ziping Sun, Yicheng Ni, Jian Zhang*, Zhiqi Yin*. Tumor Necrosis Targeted Radiotherapy of Non-Small Cell Lung Cancer Using Radioiodinated Protohypericin in a Mouse Model. Oncotarget, 2015, accepted (IF 6.359)
[2]Kuiniu Zhu, Cuihua Jiang, Y.S. Tian, N. Xiao, Zhengfeng Wu, Yonglan Ma, Zi Lin, Sshengzuo Fang, Xulan Shang, Kang Liu, Jian Zhang, Baolin Liu*, Zhiqi Yin*. Two triterpeniods from Cyclocarya paliurus (Batal) Iljinsk (Juglandaceae) promote glucose uptake in 3T3-L1 adipocytes: the relationship to AMPK activation. Phytomedicine, 2015, DOI:10.1016/j.phymed.2015.05.058 (IF 3.126)
[3]Xuejiao Liu, Yuanbo Feng, Cuihua Jiang, Bin Lou, Yue Li, Wei Liu, Nan Yao, Meng Gao, Yun Ji, Qingqing Wang, Dejian Huang, Zhiqi Yin*, Ziping Sun, Yicheng Ni, Jian Zhang*. Radiopharmaceutical evaluation of 131I-protohypericin as a necrosis avid compound. Journal of Drug Targeting, 2015, 23(5): 417-426. (IF 2.741)
[4]Yonglan Ma, Cuihua Jiang, Nan Yao, Yue Li, Qingqing Wang, Shengzuo Fang, Xulan Shang, Ming Zhao, Chuntao Che, Yicheng Ni, Jian Zhang, Zhiqi Yin*. Antihyperlipidemic effect of Cyclocarya paliurus (Batal.) Iljinskaja extract and inhibition of apolipoprotein B48 overproduction in hyperlipidemic mice. Journal of Ethnopharmacology, 2015, 166: 286-296 (IF 2.998)
[5]Dongjian Zhang(#), Dejian Huang, Yun Ji(#), Cuihua Jiang, Yue Li, Meng Gao, Nan Yao, Xuejiao Liu, Haibo Shao, Su Jing, Yicheng Ni, Zhiqi Yin*, Jian Zhang*. Experimental evaluation of radioiodinated sennoside B as a necrosis-avid tracer agent. J Drug Target, 2015, 23(2): 180-190 (IF 2.741)
[6]Xuejiao Liu, Cuihua Jiang,Yue Li, Wei Liu, Nan Yao, Meng Gao,Yun Ji, Dejian Huang, Zhiqi Yin, Ziping Sun, Yicheng Ni, Jian Zhang*. evaluation of Hypericin: Effect of Aggregation on Targeting Biodistribution. Journal of Pharmaceutical Sciences, 2015, 104(1): 215-222 (IF 2.59)
[7]Yun Ji, Cuihua Jiang, Xueli Zhang, Wei Liu, Meng Gao, Yue Li, Junhu Wang, Qingqing Wang, Ziping Sun, Xiao Jiang, Nan Yao, Xiaoning Wang, Zhijun Fang, Zhiqi Yin*, Yicheng Ni, Jian Zhang. Necrosis-targeted combinational theragnostic approach to treat cancer. Oncotarget, 2014, 5(10): 2934-2946 (IF 6.359)
[8]Ming Zhao, Xianming Zhang, Yan Wang, Min Huang, Jin-Ao Duan, Tanja Gödecke, Karina M. Szymulanska-Ramamurthy, Zhiqi Yin, Chun-Tao Che. Germacranes and m-Menthane from Illicium lanceolatum. Molecules, 2014,19, 4326-4337 (IF 2.428)
[9]Cuihua Jiang, Nan Yao, Qingqing Wang, Jinghua Zhang, Yan Sun, Na Xiao, Kang Liu, Fang Huang, Shengzuo Fang, Xulan Shang, Baolin Liu, Yicheng Ni, Zhi-Qi Yin*, Jian Zhang. Cyclocarya paliurus extract modulates adipokine expression and improves insulin sensitivity by inhibition of inflammation in mice. Journal of Ethnopharmacology, 2014, 153(2): 344-351 (IF 2.755)
[10]Yun Ji,Ying Zhan, Cuihua Jiang, Xiao Jiang,Meng Gao, Wei Liu, Yue Li, Junhu Wang, Qingqing Wang, Marlein Miranda Cona, Nan Yao, Xiaoning Wang, Zhijun Fang, Zhiqi Yi*, Jian Zhang, Ziping Sun and Yicheng Ni. Improvement of solubility and targetability of radioiodinated hypericin by using sodium cholate based solvent in rat models of necrosis. J Drug Target, 2014, 22(4):304-312 (IF 2.768)
[11]Jun-Min Shi, Liang-Liang Bai, Dong-Mei Zhang*, Anita Yiu, Zhi-Qi Yin, Wei-Li Han, Jun-Shan Liu, Yong Li, Deng-Yue Fu, Wen-Cai Ye*. Saxifragifolin D induces the interplay between apoptosis and autophagy in breast cancer cells through ROS-dependent endoplasmic reticulum stress, Biochemical Pharmacology, 2013, 85(7): 913-926 (IF 4.576)
[12]Xiao-Jun Huang, Lei Wang, Meng Shao, Shu-Zhi Hu, Ren-Wang Jiang, Xin-Sheng Yao, Yao-Lan Li, Zhi-Qi Yin*, Ying Wang* and Wen-Cai Ye*. Oleonin, the first secoiridoid with 1 alpha-configuration from Ligustrum lucidum , RSC Advances, 2013, 3(37), 16300-16303. (IF 2.562)
[13]Qingqing Wang, Cuihua Jiang, Shengzuo Fang, Junhu Wang, Yun Ji, Xulan Shang, Yicheng Ni, Zhiqi Yin*, Jian Zhang. Antihyperglycemic, antihyperlipidemic and antioxidant effects of ethanol and aqueous extracts of Cyclocarya paliurus leaves in type 2 diabetic rats. Journal of Ethnopharmacology, 2013, 150: 1119-1127 (IF 2.755)
[14]Jun Chu, Songlin Li, Zhiqi Yin*, Wencai Ye, Qingwen Zhang*. Simultaneous quantification of coumarins, flavonoids and limonoids in Fructus Citri Sarcodactylis by high performance liquid chromatography coupled with diode detector. Journal of Pharmaceutical and Biomedical Analysis, 2012, 66: 170-175. (IF 2.967)
[15]Lei Wang, Zhiqi Yin*, Qingwen Zhang, Xiaoqi Zhang, Dongmei Zhang, Kang Liu, Yaolan Li, Xinsheng Yao and Wencai Ye. Five New C21 Steroidal Glycosides from Periploca sepium. Steroids, 2011, 76:238-243 (IF 3.106)
[16]Lei Wang, Zhqi Yin*, Ying Wang, Xiaoqi Zhang, Yaonan Li, Wencai Ye. Perisesaccharides A-E, New Oligosaccharides from the Root Barks of Periploca sepium. Planta Medica, 2010,76: 909-915 ( IF 2.037)
联系方式
Tel:025-86185371(O),86185375(L),13813879136
E-mail:chyzq2005@126.comorcpu-yzq@cpu.edu.cn
通讯地址:
江苏省南京市鼓楼区童家巷24号中国药科大学天然药化教研室(210009)
江苏省南京市江宁区龙眠大道639号中国药科大学天然药化教研室(211198)